Stuck in the Middle: Drugging the Ubiquitin System at the E2 Step
نویسندگان
چکیده
The discovery of a small-molecule allosteric inhibitor of the CDC34 ubiquitin-conjugating enzyme (E2) by Ceccarelli et al. raises the possibility that it will be generally feasible to selectively inhibit ubiquitin transfer at this central step in the ubiquitin pathway.
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عنوان ژورنال:
- Cell
دوره 145 شماره
صفحات -
تاریخ انتشار 2011